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1317 10th Avenue W., Mobridge, SD 57601
Provides pharmacy services such as prescription refills and transfers, medication therapy management, immunizations, durable medical equipment, long term care, and over the counter medications. This is a medical disposal take-back site. Customers can download the PocketRx mobile app to refill medications, set medication reminders, manage prescriptions, and have medications delivered to your door.
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112 W. Main Street, Parkston, SD 57366
A retail pharmacy that provides prescriptive and over the counter medications. Also serves as a medical disposal site.
Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications. Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
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320 W. 4th Street, Sioux Falls, SD 57104
A secure box is available for drop off of unwanted, unused, or expired medications.
No liquid medication is accepted
A separated 'sharps' container is available
A separate container is designated for chemotherapy drugs
The drop box is located on the left side of the Law Enforcement Center front desk. People can bring their medication in and drop in the box. No information is required and no forms are necessary.
2120 Mount Rushmore Road, Rapid City, SD 57701
Pharmacy services, vaccinations, and medical equipment/supplies are offered. All 3 locations serve as medication disposal sites.
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2825 1st Avenue, Spearfish, SD 57783
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
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3000 S. Minnesota Avenue, Sioux Falls, SD 57105
Provides pharmacy services including immunizations and vaccines, prescription refills, transfers, and disposal sites, $4.00 Generics service, pet medications, and Medicare assistance.
Also sells OTC medications, vitamins & supplements, medical supplies, first aid, smoking cessations, and family planning products.
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201 Main Avenue S., Wagner, SD 57380
Pharmacy services include compounding, immunizations, medication synchronization, Medicare open enrollment, medication services to long-term care facilities, and carries a wide variety of over the counter drugs and medical equipment.
​This pharmacy is also a medication disposal site.
Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications.
Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
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911 11th Street S.E. Suite 100, Watertown, SD 57201
Pharmacy services include immunizations, prescription refills, health screenings, and a medication disposal drop box.
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Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications.
Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
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118 8th Avenue S., Faulkton, SD 57438
Pharmacy services include immunizations, medication synchronization, Medicare open enrollment, medication services to long-term care facilities, and carries a wide variety of over the counter drugs and medical equipment.
​This pharmacy is also a medication disposal site.
Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications. Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
Customers can use the PocketRx mobile app to request medication refills, set medication reminders, and look up their medications.
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5200 W. 60th Street N., Sioux Falls, SD 57107
Retail pharmacy and a medication disposal site. Services provided are immunizations, medical equipment/supplies, smoking cessation, and pain management. Also sells OTC medications.
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100 Lake Traverse Drive, Sisseton, SD 57262
The Woodrow Wilson Keeble Memorial Health Care Center is accredited by Joint Commission on Accreditation of Healthcare Organization, Inc. (JCAHO) serving Native American people living in or near Roberts County.
Services include Behavioral Health, Dental, Diabetes Care, Health Promotion/Disease Prevention, Laboratory, Nursing, Radiology, Optometry, Pharmacy (Prescription Assistance - Enrolled members of a Native American tribe can get free prescriptions by visiting their local IHS), Primary Care, Public Health Nursing, Physical Therapy, Specialty Clinic (OB/GYN), Weight Loss/Nutrition, Well Child Care, Men/Women's Health, and Medication Disposal.
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Cultural Transition CounselingClinical Psychiatric EvaluationDialysis CentersDiabetes Management ClinicsGovernment Subsidized Prescription Drug BenefitsPhysical ExaminationsIndividual CounselingCommunity ClinicsMental Health Expense AssistanceEye ExaminationsPsychological AssessmentMedication DisposalNative American CommunityOphthalmologyIndian Health Service ClinicsDental CareGeneral Counseling ServicesPrescription Expense AssistanceMental Health ScreeningCultural Heritage Groups
2100 Broadway Avenue, Yankton, SD 57078
Provides pharmacy services including immunizations and vaccines, prescription refills, transfers, and disposal sites, $4.00 Generics service, pet medications, and Medicare assistance.
Also sells OTC medications, vitamins & supplements, medical supplies, first aid, smoking cessations, and family planning products.
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401 Second Street, Ida Grove, IA 51445
Pharmacy services include immunizations, prescription refills, health screenings, and a medication disposal drop box.
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Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications.
Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
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410 Walnut Street, Suite 104, Yankton, SD 57078
​The Yankton County Sheriff's Department is a law enforcement agency for Yankton County which also runs the Yankton County Jail.
Also, shares year-round prescription drug take-back site with City of Yankton Police Department.
The County Sheriff is the contact for mental health holds, county jail information, and fingerprinting (call for specifics).
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825 Third Street, Jackson, MN 56143
Pharmacy services include immunizations, prescription refills, health screenings, and a medication disposal drop box.
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Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications.
Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
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300 Kansas City Street, Rapid City, SD 57701
Whether it's serving civil papers, warrants, patrolling Pennington County or investigating crimes, the employees in the Law Enforcement Division are always ready to assist Pennington County residents and visitors. The department is a year-round prescription drug take-back site.

The County Sheriff is also the contact for mental health holds, burning bans, county jails/correctional facilities (including Western SD Juvenile Center), and fingerprinting for pistol permits. Other reasons for fingerprinting in Pennington County, are done by Rapid City police at 605-394-6612.
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2020 Broadway Avenue, Yankton, SD 57078
Provides pharmacy services including: immunizations and vaccines, prescription refills, transfers, and disposal sites; pet Medications, Medicare assistance.
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1250 Stanford Street, Vermillion, SD 57069
The Vermillion Police Department is responsible for serving and protecting the citizens of Vermillion. Community programs include DARE, Report It, ALICE, Red Tag Nuisance Abatement, Ride Along program, and year-round prescription drug take-back site.
What's Here
Juvenile Delinquency PreventionDrug Use Disorder Education/Prevention911 ServicesMunicipal PoliceAmbulance ServicesMedication DisposalTobacco Use Education/PreventionCity Government Departments/OfficesAlcohol/Drug Impaired Driving PreventionAlcohol Use Disorder Education/PreventionCritical Incident Stress DebriefingGeneral Crime Reporting
304 Main Avenue, Brandon, SD 57005
Responsible for serving and protecting the citizens of Brandon. Sioux Falls Metro (911) dispatches for Brandon. Strives to increase safety and reduce crime.
Offers year-round prescription drug take-back sites that are available on site. Members of the public may drop off any unused prescription or nonprescription drugs as well as any "sharps," such as needles or epi-pens.
Participates in the Crime Free Multi-Housing Program - a partnership between law enforcement, managers, and tenants to help keep drug and criminal activity out of rental properties. Maintains minimum standards for tenants and managers to participate in the program.
Processes Peddler's License applications.
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3200 SD Highway 34, Suite 13, Pierre, SD 57501
The Pierre Police Department is responsible for serving and protecting the citizens of Pierre.
Provides fingerprinting services for area residents.
Medication secured drop box - walk in lobby.
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300 Kansas City Street, Rapid City, SD 57701
Drop prescription bottles in the bright green box in the main lobby of the police department, a separate 'sharps' container is available.
318 Studdart Avenue, Graceville, MN 56240
Pharmacy services include immunizations, prescription refills, health screenings, and a medication disposal drop box.
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Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications.
Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
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207 J Avenue, Suite 3, Eureka, SD 57437
Pharmacy services include Med Part D counseling, durable medical equipment, medication synchronization, private consultations, and free prescription delivery.
This is also a medication disposal site.
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911 W. Cedar Street Suite 1, Beresford, SD 57004
Pharmacy services include immunizations, prescription refills, health screenings, and a medication disposal drop box.
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Medication disposal drop-boxes for expired, unused or unwanted controlled, non-controlled, and over the counter medications, including pet medications.
Items that are NOT accepted include: trash, regulated medical waste, sharps, syringes, thermometers, hazardous waste, aerosols, illicit drugs, or commercial waste.
What's Here
4101 W. Memory Circle, Suite 135, Sioux Falls, SD 57107
Providing prescription and over the counter medication services, infusion therapy, intravenous medication, and supply a wide range of retail supplies.
Most Avera Pharmacy locations have a medication disposal site available.
