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Founded in 1979, the National Down Syndrome Society (NDSS) empowers individuals with Down Syndrome and their families by driving policy change, providing resources, engaging with local communities, and shifting public perceptions. The organization's work is achieved through three key areas of programming: Resources & Support, Policy & Advocacy, and Community Engagement.

Purpose is to promote the awareness, acceptance, and inclusion of children and adults with Down syndrome in South Dakota.

Families of infants through preschoolers with Down Syndrome are welcome to take part in a private online community and regularly scheduled meetups, including a monthly "Big Event."

Provides information about Down Syndrome, direction to resources, and networking opportunities. For a schedule of meetings and family fun events, visit the website.