HDSA, with its headquarters in New York City, currently has 54 volunteer-led Chapters and Affiliates across the United States. Chapters and Affiliates support HDSA's mission by bringing community-based services, awareness and grassroots fundraising to strengthen resources to families affected by HD.

Education Public Awareness: Hosts education days each year to bring in guest speakers to discuss different topics about HD such as discoveries about the disease, new and promising research, discoveries about the progression of the disease and resources available to families and patients. Outreach: Local chapter support available online through their Chapter website and social media channels such as Facebook. By keeping a constant stream of information online, patients and families can find support and information at all hours of the day or night. Support Group Hosts a monthly support group meeting for families who are affected by HD twice a month. This group reviews caregiver support, discusses genetic testing, care options and serves as a general sounding board to support one another through the journey of this disease. Support groups are offered face-to-face and on-line. Visit website to find a group. Advocacy Members work with the medical community including medical students, social workers, and police to create an understanding environment for those who are suffering from Huntington's disease.