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Offers primary care, mental health care, treatment for post traumatic stress disorder (PTSD), and suicide prevention. Also offers transitional and supportive housing for veterans experiencing homelessness. Gun safety locks are available through the Suicide Prevention Coordinator.

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

A 25-bed critical access hospital that also houses an 84-bed senior care facility and specialty clinic for visiting physicians. The hospital offers 24-hour emergency service, inpatient and outpatient care, and hospice.

Provides a full range of primary healthcare services including physical exams, chronic disease management, acute illness management, physicals, well child exams, children/adolescent/men/women healthcare services, immunizations, telemedicine related to medical and mental health needs, certified laboratory services, All Women Count services, assistance with Marketplace insurance enrollment, and allergy injections. Nurse triage available for after-hours calls. Situation will be assessed by a registered nurse with further guidance provided. Strives to meet the needs of all patients, including the underinsured and underserved and offers services at a reduced rate to those who qualify.

Horizon Health - Eagle Butte is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, prenatal care, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Services include emergency room, ambulance, cardiac rehabilitation, chronic care management, gastroscopy, intensive/coronary care unit, mammograms, pulmonary rehab, physical, speech, and occupational therapies, and a sleep lab. Provides monthly services for blood pressure/blood sugars, walk-in immunizations, and foot care clinic. Also includes outreach clinics/telemedicine services for a variety of health needs.

Provides clinic services such as primary care, women's health, men's health, physicals, preventative medicine, pediatric care, enhanced laboratory services, immunizations, and health education.

Offers the following: hospital care, surgical services, diagnostic services, therapy services, respiratory care, and intravenous therapy.

A primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs. Services include Family medicine, Bone density screening, BOTOX® cosmetic rejuvenation, Concussion management, Glycolic facial peels, Laboratory, Occupational therapy, Office-based surgery, Physical therapy, Speech therapy, and X-ray.

Located on the Pine Ridge Reservation, it is an ambulatory care center with outpatient services. Services include primary care, pediatric, women's health, optometry, dental, behavioral health, podiatry, radiology, and laboratory tests.

Provides patients with cancer treatments and caring support. Services include support services (e.g. assisting patients with financial resources and making referrals), radiation therapy, chemotherapy, PET scanning, clinical trials, and a pharmacy.

Clinic services offered include Preventative Care, Pediatrics, Pregnancy Care, Women's Health, 3D Mammograms, Lab Work, and Imaging.

Offering multi-specialty health care services such as 3D mammography, family medicine, lab, x-ray, and ultrasound services, obstetrics and gynecology (OBGYN), pediatrics, prenatal care, physical therapy, sexual health and intimacy care, and women's health services. Also offers behavioral health services such as dialectical behavioral therapy (DBT) and eye movement desensitization and reprocessing (EMDR) therapy.

The Avera Winner Medical Clinic is a member of the Avera McKennan Primary Care Network and Avera Health. Services include laboratory, x-ray, and Beltone hearing aid specialist on-site monthly.

Horizon Health - Mission is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, prenatal care, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Sanford Health Mitchell offers the following specialties: 3D mammography, colonoscopy, family medicine, health coaching, immunizations, internal medicine, laboratory, MRI, nephrology, neurosurgery, OB/GYN, orthopedics, pediatric cardiology, physical medicine & rehabilitation, pulmonology, ultrasound, vascular care, vascular surgery, walk-in and x-ray.

An outpatient clinic providing primary care, laboratory and pathology testing, mental health care, and suicide prevention.

Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.

Provides quality home health care to residents of the Sioux Empire, Vermillion, and Chamberlain communities. Services offered include care for heart conditions, complex wound care, diabetes education and assessment, disease and symptom management, education on a newly diagnosed medical condition, home health aide, home infusion therapy education, home safety education, medication education, occupational therapy, pain management, pediatric care, physical therapy, postsurgical care, skilled nursing, speech therapy, and rehabilitation therapy while recovering from an orthopedic condition or hospital stay. They are most appropriate for individuals recently discharged from the hospital and are not fully recovered such as after surgery or new diagnosis, individuals recently diagnosed with an illness and needing education, and individuals who have a chronic condition that needs frequent clinical assessment such as diabetes, kidney, stroke, heart or lung disease.

Provides emergency care, pediatrics, family medicine, general practice medicine, inpatient and outpatient rehabilitation therapy, medical imaging, OBGYN, 3D mammography (Free mammogram and cancer screening program 'We've Got You Covered'), chemotherapy, laboratory services, internal medicine, general surgery, dialysis, home health, hospice, intensive care, outpatient treatment, same day surgery, orthopedic surgery, podiatric surgery, prenatal care, and swing bed.

Services include - 24-hour physician-covered emergency department, Diabetes education, Full-service laboratory, Medical imaging services, Digital mammography, Physical therapy, Occupational therapy, Speech therapy, Radiology, and Medication disposal.

Offers women's health services such as annual exams, personalized maternity care, ultrasound, laboratory tests, home-delivered specialty medications, radiology and imaging, and childbirth education classes.

Providing local medical care, assessments, treatments and referrals.

Offers the following: hospital care, surgical services, diagnostic services, therapy services, respiratory care, and intravenous therapy.

Providing family medicine (including flu shots).