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Clinic services include primary care, children's health, pregnancy and birth, radiology and imaging, laboratory and women's health. This location also offers sharps disposal.

A full service hospital and family medicine clinic providing acute, emergency, and medical care. This is also a medication disposal site.

A medical clinic offering family medicine, obstetric and general surgery services.

A multi-specialty health care clinic with a variety of specialties such as: cardiology; family practice; pediatrics; radiology; urology; orthopedics; general surgery; internal medicine; OB/GYN; palliative medicine; geriatric medicine; full service laboratory; prenatal care; pulmonology; nephrology; rheumatology; physical medicine; and diagnostic imaging center.

Sanford Health Mitchell offers the following specialties: 3D mammography, colonoscopy, family medicine, health coaching, immunizations, internal medicine, laboratory, MRI, nephrology, neurosurgery, OB/GYN, orthopedics, pediatric cardiology, physical medicine & rehabilitation, pulmonology, ultrasound, vascular care, vascular surgery, walk-in and x-ray.

Located on the Pine Ridge Reservation, it is an ambulatory care center with outpatient services. Services include primary care, pediatric, women's health, optometry, dental, behavioral health, podiatry, radiology, and laboratory tests.

Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.

Native Women's Health Care provides Obstetrical and Gynecological (OB/GYN) services to women who are eligible (patients are mainly from Rapid City and Red Shirt Table communities, but also any Native American Woman who is eligible for IHS care from any Indian community or tribal land), including consultation and health education services to promote early and adequate prenatal care for pregnant Native American women residing in the Rapid City community. The clinic follows federal guidelines set forth by IHS; therefore all patients must be registered/eligible with the Oyate Health Center before making an appointment. Also, offers Sexual Assault Forensic Exams during clinic hours.

Horizon Health - Howard Medical is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

Offers women's health services such as annual exams, personalized maternity care, ultrasound, laboratory tests, home-delivered specialty medications, radiology and imaging, and childbirth education classes.

Sanford Health's family medicine clinics provide care for the whole family - from babies to grandparents. Treats a variety of illnesses and injuries; from annual physicals, regular checkups, baby wellness, vaccinations and school and athletic physicals as well as offering OB/GYN and prenatal care.

Offers a wide range of services in general medicine, family medicine, geriatrics, minor surgical procedures, and routine annual exams. Services include physicals and annual exams, pre-employment physicals, wellness exams, athletic physicals, access to various specialists, biopsies and minor surgical procedures, urine drug testing, immunizations, patient education, preventive healthcare, and routine pre-natal and obstetrics care.

A full service hospital and family medicine clinic located in the community of Aberdeen, SD. The facility provides acute, emergency, and medical care, full lab, with diagnostic testing, outpatient infusion, respiratory therapy, radiology, rehabilitation, diabetes care, pharmacy, flu shots, surgery, women's center/labor and delivery, oncology/cancer, and cardiology/heart.

A family practice and women's health clinic offering comprehensive care for newborns, pediatrics, adults, and geriatric patients. Provides preventive care, annual examinations, immunizations, obstetrical care, prenatal care, women's health care, radiology, lab services, and mental/behavioral health services.

Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), Nutrition Services, and Women's Health. The take-back site is available.

Licensed to operate 81 acute care hospital beds including Labor and Delivery, Telemetry, Critical Care, and a general hospital. Hospital services also include a 24-hour emergency department, surgery capabilities, Interventional Cardiology, Cardiology, Dermatology, Ear, Nose, & Throat, Nephrology, Pulmonology, Urology, Rehabilitation Services (PT and OT), Wound Care, Orthopedics, and services providing diagnostics and imaging services. -

A full service hospital and family medicine clinic located in the community of Chamberlain, SD. The facility provides acute, emergency, and medical care.

The Avera Medical Group Gregory is a member of the Avera McKennan Primary Care Network and Avera Health. Services include children's health, pregnancy and birth, primary care, urgent care, and women's health.

The multi-campus facilities of Avera McKennan Hospital and University Health Center include: a network of primary and specialty clinics, Avera Behavioral Health Center, Avera Heart Hospital of South Dakota, Avera Living Well Center, Avera Prince of Peace long-term care and retirement community. The hospital's main campus includes the Avera Cancer Institute, Plaza 1, Plaza 2, Plaza 3 and Plaza 4, Avera Medical Group 7th Avenue, Avera Surgery Center, and the Center for Family Medicine.

Clinic services offered include Preventative Care, Pediatrics, Pregnancy Care, Women's Health, 3D Mammograms, Lab Work, and Imaging.

Horizon Health - De Smet Medical is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Sanford Health's family medicine clinics provide care for the whole family - from babies to grandparents. Treats a variety of illnesses and injuries; from annual physicals, regular checkups, baby wellness, vaccinations and school and athletic physicals as well as offering OB/GYN and prenatal care.

Clinic locations offer family care to Sioux Falls and the surrounding area. Provides a variety of services for family and primary care (including flu shots) as well as prenatal care and OB/GYN. Other health services include yearly checkups, treatment of minor illnesses, and management of chronic conditions.

Sanford Health's family medicine clinics provide care for the whole family - from babies to grandparents. Treats a variety of illnesses and injuries; from annual physicals, regular checkups, baby wellness, vaccinations and school and athletic physicals as well as offering OB/GYN and prenatal care.