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Coteau des Prairies (CDP) Health Care System is a 25-bed, critical access acute care, community non-profit hospital serving approximately 21,000 residents in the Glacial Lakes Region in north east South Dakota, and west central Minnesota. CDP Health Care System owns and operates the attached certified rural health clinic in Sisseton, the Browns Valley Clinic in Browns Valley, Minnesota, and the Rosholt Clinic in Rosholt, South Dakota.​ Services available at Coteau des Prairies Hospital and Clinic include In-patient and out-patient surgery, Swing Beds, Emergency Room, Cardiac Rehab, Laboratory Services, Radiology, Mammography, Therapy Services, Fitness Center, Medication disposal, Diabetic Education, Telehealth, Medical-Assisted Treatment (MAT), and Women's Health. The take-back site is available.

Offers the following services to males and females in their reproductive years on a sliding scale - male/female reproductive health exams, birth control services, sexually transmitted infection testing, treatment and education, pregnancy testing, and educational programs to community groups and schools on request, regarding sexually transmitted infections and birth control methods. *Due to Title X funding, parental consent is not required for those under 18.

A full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Bison Clinic is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

Horizon Health - Martin Medical is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Horizon Health - Alcester Medical is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Offering multi-specialty health care services such as 3D mammography, family medicine, lab, x-ray, and ultrasound services, obstetrics and gynecology (OBGYN), pediatrics, physical therapy, sexual health and intimacy care, and women's health services. Also offers behavioral health services such as dialectical behavioral therapy (DBT) and eye movement desensitization and reprocessing (EMDR) therapy.

Offers women's health services such as annual exams, personalized maternity care, ultrasound, laboratory tests, home-delivered specialty medications, radiology and imaging, and childbirth education classes.

Provides family medicine, OB/GYN, pediatrics, behavioral health, and mammography.

Falls Community Health is a family practice medical clinic and dental clinic with emphasis on health promotion and disease prevention. The Community Health Center was established in 1979 with its goal being to remove the barriers, primarily financial, that exist and limit the access of lower income individuals or families seeking primary health care services.  ​Services for the general public include family health, lab radiology, well-child care, immunizations, family planning (including birth control, STD screening and treatment), patient education, and dental care. Services for established clinic patients include outpatient mental health and substance abuse counseling, psychiatry services, transportation assistance (transporter of last resort), and pharmacy assistance to clients of the Falls Community Health Care Clinic.

A family practice and women's health clinic offering comprehensive care to newborns, pediatrics, adult, and geriatric patients. Services include preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, radiology, and lab services.

Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.

Sanford Vermillion Medical Center is a full service hospital and clinic providing the following services: 24-Hour Emergency Care, Ground and Air Ambulance support/access, medical, surgical, pediatric, and obstetrical care, outpatient nursing services (including chemotherapy), family medicine clinic, diagnostic services, home care and hospice programs, outpatient mental health counseling, rehabilitation therapies, respiratory care, acute care hours Saturday morning, Sunday afternoon, and weekday evenings, sports medicine, community health education, specialty outreach services (cardiology, diagnostic radiology, ENT surgery, general surgery, neurology, nephrology, oncology, orthopedics, podiatry, psychiatry, pulmonology, urology, and vascular surgery), and University of South Dakota student health services. Vermillion Medical Center has a teaching affiliation with USD Health Science Program.

Services available include hospital (inpatient, outpatient and observation), swing bed (skilled nursing services), dietitian and nutrition services, rehabilitation services, laboratory services, X-ray and CT services, MRI, mobile mammogram and Dexa scan, clinic services, emergency services 24/7/365, telemental health, and various outreach services.

Falls Community Health is a family practice medical clinic and dental clinic with emphasis on health promotion and disease prevention. The Community Health Center was established in 1979 with its goal being to remove the barriers, primarily financial, that exist and limit the access of lower income individuals or families seeking primary health care services.  ​Services for the general public include family health, lab radiology, well-child care, immunizations, family planning (including birth control, STD screening and treatment), patient education, and dental care. Services for established clinic patients include outpatient mental health and substance abuse counseling, psychiatry services, transportation assistance (transporter of last resort), and pharmacy assistance to clients of the Falls Community Health Care Clinic.

Offers a wide range of services in general medicine, family medicine, geriatrics, minor surgical procedures, and routine annual exams. Services include physicals and annual exams, pre-employment physicals, wellness exams, athletic physicals, access to various specialists, biopsies and minor surgical procedures, urine drug testing, immunizations, patient education, preventive healthcare, and routine pre-natal and obstetrics care.

Native Women's Health Care provides Obstetrical and Gynecological (OB/GYN) services to women who are eligible (patients are mainly from Rapid City and Red Shirt Table communities, but also any Native American Woman who is eligible for IHS care from any Indian community or tribal land), including consultation and health education services to promote early and adequate prenatal care for pregnant Native American women residing in the Rapid City community. The clinic follows federal guidelines set forth by IHS; therefore all patients must be registered/eligible with the Oyate Health Center before making an appointment. Also, offers Sexual Assault Forensic Exams during clinic hours.

Avera Medical Group Brookings is a multi-specialty medical group providing clinic laboratory, digital mammography, imaging and x-ray, 3D mammography, ear, nose and throat, family practice, general surgery, infusion/chemotherapy, internal medicine, obstetrics & gynecology, orthopedics, outreach specialists, pediatrics, physical therapy, dermatology, podiatry, and urology. A Coordinated Care Team is available to help identify resource support for community and primary healthcare needs; facilitation and connection to long-term counseling services to meet mental health needs, and clinic based counseling for interim or short-term support needs.

Medical services provided include: Adult Medicine - annual checkups, wellness consultations, comprehensive evaluations, preventative care, and diagnostic services. Women's Health - annual health exams, pap smears, breast health services, and routine gynecological care. Obstetrics - prenatal and postpartum care in partnership with OB/GYN specialists. Minor Surgery - laceration repair, foreign body removal, wart removal, biopsies (skin or superficial lesions), excision of ingrown toenails, fractures and sprain care. X-Rays/Laboratory Services - some of the testing is done on site. Tests that cannot be performed on site are provided at Pioneer Memorial Hospital in Viborg. Referrals - connects patients with a specialist in any area Disease Management - monitor conditions such as hypertension, thyroid disease, diabetes, cardiac conditions, etc. Therapy services including speech, physical, and occupational

A multi-specialty health care clinic with a variety of specialties such as: cardiology; family practice; pediatrics; radiology; urology; orthopedics; general surgery; internal medicine; OB/GYN; palliative medicine; geriatric medicine; full service laboratory; pulmonology; nephrology; rheumatology; physical medicine; and diagnostic imaging center.

A primary care, family medicine clinic that provides comprehensive care for the entire family through all phases of life, from childhood to senior years. Board certified physicians and physician assistants offer health care services sensitive to individual needs. Services include: outpatient counseling for adults and adolescents, family medicine, audiology/hearing aids, bone density screening, childhood & adult immunizations, general surgery, laboratory, OB/GYN, office-based surgery, sports & pre-employment physicals, and x-ray.

Offers: urgent care, 24-hour emergency room, family practice, OB/GYN, pediatrics, optometry, occupational medicine, and mammography.

Featured health services include cancer care, blood diseases and disorders, brain and spine care, dentistry, emergency and trauma, heart and vascular care, infectious disease and public health, laboratory, nutrition, pain management, pregnancy and birth, Radiology and imaging, respiratory and pulmonary care, sleep medicine, surgery, telemedicine, therapy and rehabilitation, wellness and preventive care, women's health, and wound care.

Offers a wide range of services in general medicine, family medicine, geriatrics, minor surgical procedures, and routine annual exams. Services include physicals and annual exams, pre-employment physicals, wellness exams, athletic physicals, access to various specialists, biopsies and minor surgical procedures, urine drug testing, immunizations, patient education, preventive healthcare, and routine pre-natal and obstetrics care.

Horizon Health - Faith is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Faith is also a partner with the Department of Veterans Affairs (VA) Community Care Program.

A medical clinic offering family medicine, obstetric and general surgery services.