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The multi-campus facilities of Avera McKennan Hospital and University Health Center include: a network of primary and specialty clinics, Avera Behavioral Health Center, Avera Heart Hospital of South Dakota, Avera Living Well Center, Avera Prince of Peace long-term care and retirement community. The hospital's main campus includes the Avera Cancer Institute, Plaza 1, Plaza 2, Plaza 3 and Plaza 4, Avera Medical Group 7th Avenue, Avera Surgery Center, and the Center for Family Medicine.

A full service hospital and family medicine clinic located in the community of Aberdeen, SD. The facility provides acute, emergency, and medical care, full lab, with diagnostic testing, outpatient infusion, respiratory therapy, radiology, rehabilitation, diabetes care, pharmacy, flu shots, surgery, women's center/labor and delivery, oncology/cancer, and cardiology/heart.

Custer Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include Digital mammography, Family medicine, Fracture care, Geriatric care, Minor surgical procedures, Pediatrics, including childhood immunizations, Prenatal/gynecology, Pulmonary function testing, Vaccinations, including flu vaccines, Vasectomy, and Wellness exams.

Clinic services offered include Preventative Care, Pediatrics, Pregnancy Care, Women's Health, 3D Mammograms, Lab Work, and Imaging.

Wall Monument Medical Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include Family medicine, Electrocardiogram, Laboratory, and Medical imaging.

Providing local medical care, assessments, treatments and referrals.

Sponsored by Avera, Avera St. Luke's facilities include a hospital and comprehensive retirement communities in Aberdeen and Eureka, and clinics. Services include: addiction care (residential and outpatient services), behavioral health services (inpatient and outpatient), cancer services/medical oncology and radiation oncology, cardiology, dermatology, diabetes care, diagnostic imaging, emergency and trauma care, home health and hospice, Human Performance Center, hyperbaric oxygen treatments (wounds only), kidney dialysis, long-term care, nephrology, OB/GYN, occupational health, orthopedics, pain management, pediatrics, physical medicine and rehab, podiatry, primary care (family practice and internal medicine), prenatal care, primary care clinic (Groton, SD, and Ellendale, ND), pulmonology, same-day sick visit clinic, sleep lab, spine surgery, surgery, after-hours clinic, urology, wellness services, women's specialty services, and wound care.

Providing clinical health services for all ages, including Medications for Opioid Use Disorder, senior care, maternity, pediatric, men's health, LGBTQ+ care, vaccinations, lab services, and telehealth visits. A Community Health Worker is also available to help coordinate services.

Provides care to people of all sexes and gender identities on a sliding fee scale. Confidential birth control services including birth control pills and injections (donations only or sliding scale charge). Physical exams, pap-tests, exams/testing and treatment for sexually transmitted infections (male and female patients including teens), information about all forms of birth control, infertility information and referral, pregnancy diagnosis and referrals.

Surgery (24-bed specialty hospital) and specialty care in orthopedics, internal medicine, rheumatology and urogynecology. Avera Human Performance Center focuses on the needs of people who want to improve their overall physical performance or recover from injuries through sports medicine, orthopedic, therapy, and sports performance training services. This location is also home to the Avera Addiction Care Center which features residential care for adults seeking treatment of alcohol or drug addiction.

Falls Community Health is a family practice medical clinic and dental clinic with emphasis on health promotion and disease prevention. The Community Health Center was established in 1979 with its goal being to remove the barriers, primarily financial, that exist and limit the access of lower income individuals or families seeking primary health care services.  ​Services for the general public include family health, lab radiology, well-child care, immunizations, family planning (including birth control, STD screening and treatment), patient education, and dental care. Services for established clinic patients include outpatient mental health and substance abuse counseling, psychiatry services, transportation assistance (transporter of last resort), and pharmacy assistance to clients of the Falls Community Health Care Clinic.

Horizon Health - Wessington Springs Medical is a full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT). Horizon Health - Wessington Springs Dental provides a full range of family oral health services including preventative care (check ups, fillings), restorative and cosmetic dentistry (crowns, bridges) , endodontics, and oral surgery (root canals, extractions).

A full service hospital and family medicine clinic providing acute, emergency, and medical care. This is also a medication disposal site.

Horizon Health - Aberdeen is full-service medical clinic offering the following services -preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Sanford Health's family medicine clinics provide care for the whole family - from babies to grandparents. Treats a variety of illnesses and injuries; from annual physicals, regular checkups, baby wellness, vaccinations and school and athletic physicals as well as offering OB/GYN and prenatal care.

Spearfish Monument Medical Clinic is a primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Services include audiology, ear, nose, & throat, general surgery, obstetrics & gynecology (OB/GYN), pediatrics, prenatal care, radiology, concussion management, hearing aids, laboratory, medical imaging, and ultrasound.

The Family Medicine Residency Clinic provides comprehensive care for the entire family in all phases of life, from childhood to senior years. Services include care for acute and chronic medical problems, care for expectant moms, well-baby visits and immunizations, school sports physicals, OB/GYN, prenatal care, annual check-ups, immunizations, and minor surgical procedures.

Clinic locations offer family care to Sioux Falls and the surrounding area. Provides a variety of services for family and primary care (including flu shots) as well as prenatal care and OB/GYN. Other health services include yearly checkups, treatment of minor illnesses, and management of chronic conditions.

A family practice and women's health clinic offering comprehensive care to newborns, pediatrics, adult, and geriatric patients. Services include preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, radiology, and lab services.

Monument Health is an integrated health care system with the purpose of helping patients and communities live well. Rapid City Monument Hospital provides health care services 24 hours a day / 7 days a week to the people who live in the Black Hills. The hospital has a pharmacy for medication needs as well as medication disposal. Specialties include: Anesthesiology, cancer care, critical care, dentistry, dialysis, emergency medicine, gastroenterology, general surgery, heart and vascular care, hospital medicine, hyperbaric oxygen therapy, infectious disease, laboratory services, medical imaging, neonatology, nutrition services, oral and maxillofacial surgery, pediatric and adolescent medicine, ob/gyn, pharmacy, physical therapy, prenatal care, pulmonology therapy services, women's and children's health, wound and ostomy care.

An ambulatory care center with outpatient services. Services include dental care, mental health services, public health nurse, environmental health care, optometry, laboratory, radiology, pharmacy (Prescription Assistance - Enrolled members of a Native American tribe can get free prescriptions by visiting their local IHS), podiatry, HIV Clinic, SANE services, and Fitness Center.

Horizon Health - Yankton Medical offers Medical care (behavioral health, geriatric, chronic care management, DOT physicals, physical exams, family medicine, maternal health, family planning, sexually-transmitted disease testing, nursing, health education, immunizations, preventative services, well child exams, acute care, immunizations, lab/x-ray, and women's health). Also offers Certified Application Counselors for the Health Insurance Marketplace. Horizon Health - Yankton Dental offers dental care services include cleanings, dental exams, bridges, crowns, dentures, digital x-rays, emergencies, extractions, fillings, mouth guards, partials, root canals, sealants and spacers.

Offer's women's health services such as annual exams, maternity care, prenatal care, radiology & imaging, and laboratory tests.

Sanford Webster Clinic is a community clinic for the whole family (Family Medicine), and has urgent health care hours as well.

Medical services provided include: adult medicine, women's health, obstetrics, pediatric medicine, physicals, wound care, minor surgeries, radiology, laboratory, disease management, rehabilitation and therapy services, and cardiology, podiatry, orthopedics, surgery outreach services.