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Offering multi-specialty health care services such as 3D mammography, family medicine, lab, x-ray, and ultrasound services, obstetrics and gynecology (OBGYN), pediatrics, prenatal care, physical therapy, sexual health and intimacy care, and women's health services. Also offers behavioral health services such as dialectical behavioral therapy (DBT) and eye movement desensitization and reprocessing (EMDR) therapy.

Specialty care include: Audiology, Home Based Primary Care, Lab, Mental Health, Pharmacy clinical services, Physical Therapy, Primary Care, Social Work, and Nutrition. The following programs and specialty care are available by telehealth: Cardiology, Occupational Therapy, Chronic Health Management, Oncology, Dermatology, Orthopedics, Diabetes Management, Pain Management, Endocrinology, Pharmacy Services, Gastroenterology, Prosthetics/Orthotics, Genomic Medicine, Psychiatry, Infectious Disease, Pulmonary, Mental Health, Surgery (pre-op), Nephrology, Low Vision, Neurology, Urology, and Wound Care.​

Horizon Health - White River is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Providing primary healthcare including wellness visits for children and adults, acute concerns, chronic pain issues, in-office procedures, and sports physicals.

Provides a full range of primary healthcare services including physical exams, chronic disease management, acute illness management, physicals, well child exams, children/adolescent/men/women healthcare services, immunizations, telemedicine related to medical and mental health needs, certified laboratory services, All Women Count services, assistance with Marketplace insurance enrollment, and allergy injections. Nurse triage available for after-hours calls. Situation will be assessed by a registered nurse with further guidance provided. Strives to meet the needs of all patients, including the underinsured and underserved and offers services at a reduced rate to those who qualify.

Provides a variety of services including patient care, diagnostic services, support services, chemotherapy, emergency department, heart health, Planet Heart vascular and heart screening, nursing service, maternity care, medical/surgical, newborn nursery, pediatrics, respite care, swing bed, outpatient treatment, pain management, pregnancy and childbirth, rehabilitation services, cardiac rehab, occupational therapy, physical therapy, speech therapy, sleep study lab, surgical procedures, and telehealth.

Sanford Vermillion Medical Center is a full service hospital and clinic providing the following services: 24-Hour Emergency Care, Ground and Air Ambulance support/access, medical, surgical, pediatric, and obstetrical care, outpatient nursing services (including chemotherapy), family medicine clinic, diagnostic services, home care and hospice programs, outpatient mental health counseling, rehabilitation therapies, respiratory care, acute care hours Saturday morning, Sunday afternoon, and weekday evenings, sports medicine, community health education, specialty outreach services (cardiology, diagnostic radiology, ENT surgery, general surgery, neurology, nephrology, oncology, orthopedics, podiatry, psychiatry, pulmonology, urology, and vascular surgery), and University of South Dakota student health services. Vermillion Medical Center has a teaching affiliation with USD Health Science Program.

Sanford Health's family medicine clinics provide care for the whole family - from babies to grandparents. Treats a variety of illnesses and injuries; from annual physicals, regular checkups, baby wellness, vaccinations and school and athletic physicals.

Horizon Health - Aberdeen is full-service medical clinic offering the following services -preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Also offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Huron Clinic is a Family Medicine clinic, providing medical services to patients in Huron and the surrounding area. Services include Vaccinations and flu shots: adult and childhood immunizations, Family medicine, Routine physicals: annual, school, pre-employment, work, and DOT certified exams, Allergy and immunization: therapeutic injections, and allergy shot administration, Women's health: pap tests, breast screening, contraception, and STI/STD testing, Screening: in-house laboratory testing, bone density, cancer, diabetes, cholesterol, drug, alcohol, vision, and hearing. Cardio health: EKG and blood pressure screening, Pulmonary health: nebulizer treatments, pulmonary function testing, Diabetes: screening, education, diet information, weight management, and medication management, Minor surgery: mole/lesion removal, laceration repair, skin tag removal, wart removal, and liquid nitrogen treatment, Joint injections and aspirations: cortisone injections and fluid removal, Skin Cancer Screening, and Imaging: x-rays, ultrasound, and bone density testing.

Sanford Health Pierre Clinic offers health care services for patients of all ages.

A full service hospital providing hospital services, 24-hour emergency care, laboratory services, radiology services, cardiac rehab, physical, occupational and speech therapy services, wellness services, and wound care.

Providing general and specialized medical care and occupational services. Acute care services.

Providing local medical care, assessments, treatments and referrals.

Services include obstetrics with ultrasound, delivery with intrathecal block, pediatrics with inhalation therapy and IV therapy, family practice, geriatrics, OB/GYN, prenatal care, disease management, hormone replacement therapy, and 24-hour emergency care.

Primary care clinic providing family and internal medicine to those without insurance. Specifically, treating chronic and acute conditions including diabetes, high blood pressure, cholesterol, indigestion, physicals, colds/cough/flu, eat and throat infections, sexually transmitted disease screening and treatment, and immunizations.

A family practice and women's health clinic offering comprehensive care to newborns, pediatrics, adult, and geriatric patients. Services include preventative care, annual examinations, Department of Transportation (DOT) examinations, immunizations, obstetrical care, women's health care, mental/behavioral health services, radiology, and lab services.

Medical services provided include: adult medicine, women's health, obstetrics, pediatric medicine, physicals, wound care, minor surgeries, radiology, laboratory, disease management, rehabilitation and therapy services, and cardiology, podiatry, orthopedics, surgery outreach services.

Horizon Health - Howard Medical is full-service medical clinic offering the following services - preventative screenings, acute care, chronic care management, well child visits, men's and women's health, immunizations, family planning, lab/x-ray, patient education, care management, DOT exams, after-hours access to care, and Certified Application Counselors for the Health Insurance Marketplace. Offers behavioral health services: medication management, counseling, case management, integrated care, addiction services, and Medication Assisted Therapy (MAT).

Avera Medical Group McGreevy clinic locations offer family care to Sioux Falls and the surrounding area. Provides a variety of services including regular check-ups or vaccines, plus care for injuries and illnesses.

A primary care, family medicine clinic. Board certified physicians and physician assistants offer health care services sensitive to the individual needs of you and your family. Specialties include family medicine, internal medicine, childhood and adult immunizations, and sports and pre-employment physicals.

The programs offered by this agency include community organizing and leadership development, AIDS Prevention program, Child Development program, Adult learning program, Environmental issues, Transitional housing, Cancer prevention, Fetal Alcohol Syndrome awareness program, Clearinghouse of health educational materials, Newsletter, Dakota Talk Radio, KDKO Radio 89.5 FM, diabetic nutrition program, scholarships for Native American women, women's reproductive health programs, Food Sovereignty, and community health events.

Falls Community Health is a family practice medical clinic and dental clinic with emphasis on health promotion and disease prevention. The Community Health Center was established in 1979 with its goal being to remove the barriers, primarily financial, that exist and limit the access of lower income individuals or families seeking primary health care services.  ​Services for the general public include family health, lab radiology, well-child care, immunizations, family planning (including birth control, STD screening and treatment), patient education, and dental care. Services for established clinic patients include outpatient mental health and substance abuse counseling, psychiatry services, transportation assistance (transporter of last resort), and pharmacy assistance to clients of the Falls Community Health Care Clinic.

Provides clinic services such as primary care, women's health, men's health, physicals, preventative medicine, pediatric care, enhanced laboratory services, immunizations, and health education.

Provides primary care services.