The Vermillion Police Department is responsible for serving and protecting the citizens of Vermillion. Community programs include DARE, Report It, ALICE, Red Tag Nuisance Abatement, Ride Along program, and year-round prescription drug take-back site.

Health Connect of South Dakota: Strives to provide all South Dakotans access to qualitative, authenticated, independent sources of health information. Provides South Dakotans with free up-to-date health information on a variety of medical and safety issues. As needed, information and referrals to other organizations who may have additional pertinent information is available along with information on support groups and national agencies. Manages the Sioux Empire Coalition and the Sioux Empire Coalition for Youth and Young Adults and provides facilitation for various evidence based health programs. Can provide a household goods voucher for Savers. Call for more information. Member of the Helpline Center Network of Care.

Substance use programming providing chemical abuse assessments, groups, and individual services. Classes/workshops and prevention programming available for middle schools and communities. Walk-in assessments and telehealth services available.

The SEPRC works with others across the state to provide prevention resources, training and technical assistance through program development and training. Offers a 12-hour diversion class for individuals aged 17 - 20 years, designed for individuals who may be making high-risk choices and aim to change drinking and drug use behaviors.

Offers mental health and substance use services as well as both family and individual case management services which include comprehensive child/adolescent/family services, comprehensive adult/family services, adult/adolescent/family substance abuse services, and outpatient psychiatric medical services. ​Walk-in assessments available during regular business hours and emergency mental health crisis support services available 24 hours a day / 7 days a week. Telehealth services also available.

Offers patient education in the community and in schools to raise awareness on how to lower one's risk for chronic health problems and infectious illnesses. Topics include cancer awareness and screenings, injury prevention, tobacco prevention and cessation, sexually transmitted disease prevention, behavioral health awareness and screenings, drug and alcohol abuse awareness, immunizations, heart health, diabetes awareness and prevention, nutrition, and physical activity. Provides health education through health fairs, conferences, newspaper articles, health brochures, public service announcements, radio, posters, small group sessions, lunch n' learns, Facebook, and one-on-one counseling.

School-based alcohol and drug prevention and intervention counseling services for students and families. Services include: individual and group sessions, family counseling, drug and alcohol screening, tobacco screening, drug and alcohol assessments, referrals, aftercare (post treatment), and prescription drug lock boxes. Offering tele-mental health services. Must have access to computer with camera and microphone.

Serving the community of Huron with law enforcement protection 24-hours a day. Programs include Crime Stoppers: Crime reporting time line, DARE: Drug Abuse Resistance Education, Drug take back: prescription drug drop off box in the lobby of city hall, Pedestrian and Bicycle Safety: education program in the public schools, Safety City: Teaches vehicle and pedestrian safety to children, School Resource Officer: liaison between law enforcement and the youth in the community, Citizens Police Academy, and CodeRed emergency notification system.

Substance use programming providing chemical abuse assessments, groups, and individual services. Classes/workshops and prevention programming available for middle schools and communities. Walk-in assessments and telehealth services available.